Article

DIO-SPOTlight Transgenic Mouse to Functionally Monitor Protein Synthesis Regulated by the Integrated Stress Response

2024-10-15

Abstract excerpt

<h4>ABSTRACT</h4> The integrated stress response (ISR) is a core pathway for maintaining cellular proteostasis and a key regulator of translation in processes beyond the cellular response to stress. For example, the ISR regulates developmental axonogenesis, learning and memory, and synaptic plasticity in the brain. One barrier to uncovering ISR roles in health and disease is the challenge of monitoring its activi...

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Literature Corpus work: 913038cd-60d4-511c-aaab-d80d37ad0358
DOI: 10.1101/2024.10.14.618312

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