Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The special unfolded protein response in plasma cells

8 Aug 2021

Abstract excerpt

The high rate of antibody production places considerable metabolic and folding stress on plasma cells (PC). Not surprisingly, they rely on the unfolded protein response (UPR), a universal signaling, and transcriptional network that monitors the health of the secretory pathway and mounts cellular responses to stress. Typically, the UPR utilizes three distinct stress sensors in the ER membrane, each regulating a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Endoplasmic Reticulum Stress and Disease
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34368957
DOI: 10.1111/imr.13012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The special unfolded protein response in plasma cellsPMID 34368957Read ↗

The Unfolded Protein Response in Secretory Cell FunctionSemantic proximity Read ↗

Molecular physiology of plasma cell differentiationSemantic proximity Read ↗

Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and DiseaseSemantic proximity Read ↗

Rapid B cell receptor-induced unfolded protein response in nonsecretory B cells correlates with pro- versus antiapoptotic cell fate.Semantic proximity Read ↗

The Role of Endoplasmic Reticulum Stress in Human PathologySemantic proximity Read ↗

Intracellular Signaling by the Unfolded Protein ResponseSemantic proximity Read ↗

pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin.Semantic proximity Read ↗

An inter-chromosomal transcription hub activates the unfolded protein response in plasma cellsSemantic proximity Read ↗

ER chaperones in mammalian development and human diseasesSemantic proximity Read ↗

Deciphering the tissue specificity of the protein secretory pathway in humansSemantic proximity Read ↗

Novel roles of the unfolded protein response in the control of tumor development and aggressiveness.Semantic proximity Read ↗

Endoplasmic reticulum proteostasis: a key checkpoint in cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.