Article

Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonists

2024-04-20

Abstract excerpt

<h4>ABSTRACT</h4> Nucleotide-binding domain and leucine-rich repeat pyrin-domain containing protein 3 (NLRP3) is an innate immune sensor that forms an inflammasome in response to various cellular stressors. Gain-of-function mutations in NLRP3 cause autoinflammatory diseases and NLRP3 signalling itself exacerbates the pathogenesis of many other human diseases. Despite considerable therapeutic interest, the primary...

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Literature Corpus work: 5bf882ce-843f-5283-aa62-c6333f503915
DOI: 10.1101/2024.04.19.590338

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