Article

Cell type-specific biotin labeling <i>in vivo</i> resolves regional neuronal proteomic differences in mouse brain

2021-08-04

Abstract excerpt

<h4>ABSTRACT</h4> Isolation and proteomic profiling of brain cell types, particularly neurons, pose several technical challenges which limit our ability to resolve distinct cellular phenotypes in neurological diseases. Therefore, we generated a novel mouse line that enables cell type-specific expression of a biotin ligase, TurboID, via Cre-lox strategy for in vivo proximity-dependent biotinylation of proteins. U...

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Literature Corpus work: 3c866638-029e-53a5-b94d-30f34d369686
DOI: 10.1101/2021.08.03.454921

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