Back to search

Article

APRIL drives a co-ordinated but diverse response as a foundation for plasma cell longevity

2021-06-16

Abstract excerpt

Antibody secreting cells (ASCs) survive in niche microenvironments, but cellular responses driven by particular niche signals are incompletely defined. The TNF superfamily member APRIL provides a niche signal that can support the transition of transitory plasmablasts into long-lived plasma cells. Here we explore how APRIL helps to establish the biological programs that promote life in the niche, by studying the in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0c5c2f09-ad2e-5521-9dd5-e3be7df8e561
DOI
10.1101/2021.06.15.448496
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
APRIL drives a co-ordinated but diverse response as a foundation for plasma cell longevityDOI 10.1101/2021.06.15.448496
Human Bone Marrow Plasma Cell Atlas: Maturation and Survival Pathways Unraveled by Single Cell AnalysesSemantic proximity
Understanding heterogeneity of human bone marrow plasma cell maturation and survival pathways by single-cell analysesSemantic proximity
Growth-factor like gene regulation is separable from survival and maturation in antibody secreting cellsSemantic proximity
Multi-omic profiling of human antibody-secreting cells reveals diverse subsets sustain durable humoral immunitySemantic proximity
Maturation of Human Long-lived Plasma Cells Results in Resistance to Apoptosis by Transcriptional and Epigenetic RegulationSemantic proximity
Plasma cells in immunopathology: concepts and therapeutic strategies.Semantic proximity
A dichotomy in association of core transcription factors and gene regulation during the activated B-cell to plasmablast transitionSemantic proximity
PIM2 inhibition promotes MCL1 dependency in plasma cells involving integrated stress response-driven NOXA expressionSemantic proximity
Generation of human long-lived plasma cells by developmentally regulated epigenetic imprintingSemantic proximity
TAM Receptor Signaling in Immune HomeostasisSemantic proximity
The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1.Semantic proximity
Termination of CD40L co‐stimulation promotes human B cell differentiation into antibody‐secreting cellsSemantic proximity
Select a neighboring publication to make it the new centre.