Article

Maturation of Human Long-lived Plasma Cells Results in Resistance to Apoptosis by Transcriptional and Epigenetic Regulation

2021-05-23

Abstract excerpt

<h4>ABSTRACT</h4> Antibody secreting cells (ASC) circulate after vaccination and migrate to the bone marrow (BM) where a subset known as long-lived plasma cells (LLPC) persist and secrete antibodies for a lifetime. The mechanisms of how circulating ASC become LLPC are not well elucidated. Here, we show that human blood ASCs have distinct morphology, transcriptomes, and epigenetics compared to BM LLPC. LLPC acquir...

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Literature Corpus work: 01b67921-11a1-5f34-8dc4-9cbe870c02e3
DOI: 10.1101/2021.05.22.445269

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