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Understanding heterogeneity of human bone marrow plasma cell maturation and survival pathways by single-cell analyses

24 Jun 2023

Abstract excerpt

Human bone marrow (BM) plasma cells are heterogeneous, ranging from newly arrived antibody-secreting cells (ASCs) to long-lived plasma cells (LLPCs). We provide single-cell transcriptional resolution of 17,347 BM ASCs from five healthy adults. Fifteen clusters are identified ranging from newly minted ASCs (cluster 1) expressing MKI67 and high major histocompatibility complex (MHC) class II that progress to late...

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PMID: 37355988
DOI: 10.1016/j.celrep.2023.112682

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