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Article

The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1.

Nature communications - 30 Apr 2018

Zhang Boyi, Fu Da, Xu Qixia, Cong Xianling, Wu Chunyan, Zhong Xiaoming, Ma Yushui, Lv Zhongwei, Chen Fei, Han Liu, Qian Min, Chin Y Eugene, Lam Eric W-F, Chiao Paul, Sun Yu

Abstract excerpt

The senescence-associated secretory phenotype (SASP) can be provoked by side effects of therapeutic agents, fueling advanced complications including cancer resistance. However, the intracellular signal network supporting initiation and development of the SASP driven by treatment-induced damage remains unclear. Here we report that the transcription factor Zscan4 is elevated for expression by an ATM-TRAF6-TAK1 axis...

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Identifiers

PMID: 29712904
DOI: 10.1038/s41467-018-04010-4
PMCID: PMC5928226

Genes

ATM
TRAF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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