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Article

TAM Receptor Signaling in Immune Homeostasis

17 Jan 2015

Abstract excerpt

The TAM receptor tyrosine kinases (RTKs)-TYRO3, AXL, and MERTK-together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation. Deficiencies in TAM signaling have been associated with chronic inflammatory and autoimmune diseases. Three processes regulated by TAM signaling may contribute, either independently or collectively, to immune homeostasis: the negative...

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PMID: 25594431
DOI: 10.1146/annurev-immunol-032414-112103

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