Article

SARS-CoV-2 spike protein arrested in the closed state induces potent neutralizing responses

2021-01-14

Abstract excerpt

The majority of SARS-CoV-2 vaccines in use or in advanced clinical development are based on the viral spike protein (S) as their immunogen. S is present on virions as pre-fusion trimers in which the receptor binding domain (RBD) is stochastically open or closed. Neutralizing antibodies have been described that act against both open and closed conformations. The long-term success of vaccination strategies will depe...

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Literature Corpus work: edfb8ae8-1d26-5ddc-b8de-29ffc15776a8
DOI: 10.1101/2021.01.14.426695

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