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Impact of SARS-CoV-2 spike stability and RBD exposure on antigenicity and immunogenicity

8 Mar 2024

Abstract excerpt

The spike protein (S) of SARS-CoV-2 induces neutralizing antibodies and is the key component of current COVID-19 vaccines. The most efficacious COVID-19 vaccines are genetically-encoded spikes with a double proline substitution in the hinge region to stabilize S in the prefusion conformation (S-2P). A subunit vaccine can be a valuable addition to mRNA and viral vector-based vaccines but requires high stability of...

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PMID: 38459086
DOI: 10.1038/s41598-024-56293-x

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