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Influence of variant-specific mutations, temperature and pH on conformations of a large set of SARS-CoV-2 spike trimer vaccine antigen candidates.

Scientific reports - 1 Oct 2023

Stuible Matthew, Schrag Joseph D, Sheff Joey, Zoubchenok Daria, Lord-Dufour Simon, Cass Brian, L'Abbé Denis, Pelletier Alex, Rossotti Martin A, Tanha Jamshid, Gervais Christian, Maurice Roger, El Bakkouri Majida, Acchione Mauro, Durocher Yves

Abstract excerpt

SARS-CoV-2 subunit vaccines continue to be the focus of intense clinical development worldwide. Protein antigens in these vaccines most commonly consist of the spike ectodomain fused to a heterologous trimerization sequence, designed to mimic the compact, prefusion conformation of the spike on the virus surface. Since 2020, we have produced dozens of such constructs in CHO cells, consisting of spike variants with...

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Identifiers

PMID: 37779126
DOI: 10.1038/s41598-023-43661-2
PMCID: PMC10543594

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