Article

WDR-5 exhibits H3K4 methylation-independent activity during embryonic development in C. elegans

2025-08-04

Abstract excerpt

<title>Abstract</title> <p> Background Histone H3 lysine 4 methylation (H3K4me) is generally associated with active transcription and bivalent chromatin, but can also contribute to repression. In metazoans, H3K4 methylation is catalysed by KMT2 methyltransferases assembled with the core scaffolding proteins WDR5, ASH2L, and RBBP5. RBBP5 mediates complex assembly and nucleosome binding, whilst WDR5 stabilises int...

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Literature Corpus work: e3ed235e-12eb-5234-826b-83a15993cd52
DOI: 10.21203/rs.3.rs-7240678/v1

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