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Fanconi Anemia FANCM/FNCM-1 and FANCD2/FCD-2 are required for maintaining histone methylation levels and interact with the histone demethylase LSD1/SPR-5 in <i>C. elegans</i>

2018-02-14

Abstract excerpt

<h4>ABSTRACT</h4> The histone demethylase LSD1 was originally discovered as removing methyl groups from di- and monomethylated histone H3 lysine 4 (H3K4me2/1), and several studies suggest it plays roles in meiosis as well as epigenetic sterility given that in its absence there is evidence of a progressive accumulation of H3K4me2 through generations. In addition to transgenerational sterility, growing evidence for...

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Literature Corpus work
0271ea7c-83d0-5848-afc9-63b3d40dfde5
DOI
10.1101/265876
Open publication

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