Article

ATRX safeguards cellular identity during <i>C. elegans</i> development

2025-03-13

Abstract excerpt

ATRX is a member of the SWI/SNF family of ATP-dependent chromatin remodellers. In humans, loss of ATRX function leads to ATRX syndrome, a neurodevelopmental disorder. ATRX mutation in human cell lines is associated with multiple phenotypes including activation of the alternative lengthening of telomere (ALT) pathway, upregulation of retrotransposons and increased sensitivity to replication stress. However, the pri...

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Literature Corpus work: 963854e7-d7dc-532b-b278-50a82241b20f
DOI: 10.1101/2025.03.11.641662

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