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Article

The demethylase NMAD-1 regulates DNA replication and repair in the Caenorhabditis elegans germline.

PLoS genetics - 1 Jul 2019

Wang Simon Yuan, Mao Hui, Shibuya Hiroki, Uzawa Satoru, O'Brown Zach Klapholz, Wesenberg Sage, Shin Nara, Saito Takamune T, Gao Jinmin, Meyer Barbara J, Colaiácovo Monica P, Greer Eric Lieberman

Abstract excerpt

The biological roles of nucleic acid methylation, other than at the C5-position of cytosines in CpG dinucleotides, are still not well understood. Here, we report genetic evidence for a critical role for the putative DNA demethylase NMAD-1 in regulating meiosis in C. elegans. nmad-1 mutants have reduced fertility. They show defects in prophase I of meiosis, which leads to reduced embryo production and an increased...

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Identifiers

PMID: 31283754
DOI: 10.1371/journal.pgen.1008252
PMCID: PMC6638966

Genes

C5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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