Article

MORC-1 is a key component of the <i>C. elegans</i> CSR-1 germline gene licensing mechanism

2024-10-02

Abstract excerpt

The Argonaute CSR-1 is essential for germline development in C. elegans . Mutation of csr-1 downregulates thousands of germline-expressed genes, leading to the model that the CSR-1-mediated small RNA pathway promotes, or “licenses,” gene expression by an unknown mechanism. CSR-1 also silences a limited number of genes through its canonical endonucleolytic “slicer” activity. We show that the GHKL-type ATPase MORC...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 00d7375d-5107-5847-9521-c80185c41ae7
DOI: 10.1101/2024.10.02.616347

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MORC-1 is a key component of the <i>C. elegans</i> CSR-1 germline gene licensing mechanismDOI 10.1101/2024.10.02.616347Read

Regulation of MORC-1 is key to the CSR-1-mediated germline gene licensing mechanism in C. elegans.Semantic proximity Read

Two isoforms of the essential <i>C. elegans</i> Argonaute CSR-1 differentially regulate sperm and oocyte fertilitySemantic proximity Read

Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility.Semantic proximity Read

A cytoplasmic Argonaute protein promotes the inheritance of RNAiSemantic proximity Read

Arginine methylation promotes siRNA-binding specificity for a spermatogenesis-specific isoform of the Argonaute protein CSR-1Semantic proximity Read

The spatial and temporal dynamics of the nuclear RNAi-targeted RNA transcripts in <i>Caenorhabditis elegans</i>Semantic proximity Read

CSR-1 and P granules suppress sperm-specific transcription in the<i>C. elegans</i>germlineSemantic proximity Read

A role for the <i>C. elegans</i> Argonaute protein CSR-1b isoform in small nuclear RNA 3’ processingSemantic proximity Read

MORC-1 Integrates Nuclear RNAi and Transgenerational Chromatin Architecture to Promote Germline Immortality.Semantic proximity Read

ELLI-1, a novel germline protein, modulates RNAi activity and P-granule accumulation in Caenorhabditis elegans.Semantic proximity Read

The TRIM-NHL protein NHL-2 is a Novel Co-Factor of the CSR-1 and HRDE-1 22G-RNA PathwaysSemantic proximity Read

AMX-1 is necessary for proper fertility and lack of its expression induced sterility in a p53/CEP-1 dependent manner by modulating piwi expression in C. elegansSemantic proximity Read