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The <i>C. elegans</i> SET-2 histone methyltransferase maintains germline fate by preventing progressive transcriptomic deregulation across generations

2019-03-21

Abstract excerpt

Chromatin factors contribute to germline maintenance by preserving a germline-appropriate transcriptional program. In the absence of the conserved histone H3 Lys4 (H3K4) methyltransferase SET-2, C. elegans germ cells progressively lose their identity over generations, leading to sterility. How this transgenerational loss of fertility results from the absence of SET-2 is unknown. Here we performed expression profi...

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Literature Corpus work
e41dd761-b8b2-52e0-ad74-358d306b44f3
DOI
10.1101/583799
Open publication

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The <i>C. elegans</i> SET-2 histone methyltransferase maintains germline fate by preventing progressive transcriptomic deregulation across generationsDOI 10.1101/583799
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