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Article

iMUT-seq: high-resolution DSB-induced mutation profiling reveals prevalent homologous-recombination dependent mutagenesis.

Nature communications - 18 Dec 2023

Bader Aldo S, Bushell Martin

Abstract excerpt

DNA double-strand breaks (DSBs) are the most mutagenic form of DNA damage, and play a significant role in cancer biology, neurodegeneration and aging. However, studying DSB-induced mutagenesis is limited by our current approaches. Here, we describe iMUT-seq, a technique that profiles DSB-induced mutations at high-sensitivity and single-nucleotide resolution around endogenous DSBs. By depleting or inhibiting 20...

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Identifiers

PMID: 38110444
DOI: 10.1038/s41467-023-44167-1
PMCID: PMC10728174

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