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Article

Developmental progression of DNA double-strand break repair deciphered by a single-allele resolution mutation classifier.

Nature communications - 23 Mar 2024

Li Zhiqian, You Lang, Hermann Anita, Bier Ethan

Abstract excerpt

DNA double-strand breaks (DSBs) are repaired by a hierarchically regulated network of pathways. Factors influencing the choice of particular repair pathways, however remain poorly characterized. Here we develop an Integrated Classification Pipeline (ICP) to decompose and categorize CRISPR/Cas9 generated mutations on genomic target sites in complex multicellular insects. The ICP outputs graphic rank ordered...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38521791
DOI: 10.1038/s41467-024-46479-2
PMCID: PMC10960810

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