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Novel examples of NMD escape through alternative intronic polyadenylation

2025-08-31

Abstract excerpt

The nonsense-mediated mRNA decay (NMD) surveillance system detects and selectively eliminates transcripts with premature stop codons. A stop codon is considered premature if it is followed by an exon-exon junction more than 50 nucleotides downstream. Pruning of the 3’-untranslated region containing such junctions through alternative polyadenylation may provide a mechanism of NMD escape. Here, we systematically exa...

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Literature Corpus work
0a817b87-d287-5d80-9be5-b8b5bbdecff2
DOI
10.1101/2025.08.27.672552
Open publication

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Novel examples of NMD escape through alternative intronic polyadenylationDOI 10.1101/2025.08.27.672552
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