Article

Widespread intronic polyadenylation diversifies immune cell transcriptomes

2017-07-03

Abstract excerpt

Alternative cleavage and polyadenylation (ApA) can generate mRNA isoforms with differences in 3’UTR length without changing the coding region (CDR). However, ApA can also recognize intronic polyadenylation (IpA) signals to generate transcripts that lose part or all of the CDR. We analyzed 46 3’-seq and RNA-seq profiles from normal human tissues, primary immune cells, and multiple myeloma (MM) samples and created a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 29f5fc47-d2f2-521f-aa6c-2a52ad90df1f
DOI: 10.1101/158998

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Widespread intronic polyadenylation diversifies immune cell transcriptomesDOI 10.1101/158998Read

Characterization of Immune-Related Alternative Polyadenylation Events in Cancer ImmunotherapySemantic proximity Read

Unleashing alternative polyadenylation analyses with REPACSemantic proximity Read

Immune Isoform Atlas: Landscape of alternative splicing in human immune cellsSemantic proximity Read

Pervasive Intronic Polyadenylation Serves as a Potential Source of Cancer NeoantigensSemantic proximity Read

A pan-cancer interrogation of intronic polyadenylation and its association with cancer characteristicsSemantic proximity Read

PABPC1 Modulates Immunoglobulin pre-mRNA Alternative PolyadenylationSemantic proximity Read

Role of alternative polyadenylation dynamics in acute myeloid leukaemia at single-cell resolutionSemantic proximity Read

A compendium of conserved cleavage and polyadenylation events in mammalian genes.Semantic proximity Read

Identification and quantification of alternative polyadenylation sites in single cell RNA-seq data using scPAISOSemantic proximity Read

Alternative cleavage and polyadenylation: key regulatory mechanisms in health and diseaseSemantic proximity Read

Human cells contain myriad excised linear intron RNAs with links to gene regulation and potential utility as biomarkersSemantic proximity Read

A comprehensive analysis of 3’ end sequencing data sets reveals novel polyadenylation signals and the repressive role of heterogenous ribonucleoprotein C on cleavage and polyadenylationSemantic proximity Read