Article

Novel autoregulatory cases of alternative splicing coupled with nonsense-mediated mRNA decay

2018-11-09

Abstract excerpt

Nonsense-mediated decay (NMD) is a eukaryotic mRNA surveillance system that selectively degrades transcripts with premature termination codons (PTC). Many RNA-binding proteins (RBP) regulate their expression levels by a negative feedback loop, in which RBP binds its own pre-mRNA and causes alternative splicing to introduce a PTC. We present a bioinformatic framework to identify novel such autoregulatory feedback l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8ab6368d-2454-5c7b-b3cd-f16eb47c89bd
DOI: 10.1101/464404

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel autoregulatory cases of alternative splicing coupled with nonsense-mediated mRNA decayDOI 10.1101/464404Read

Nonsense-Mediated mRNA Decay Factor Functions in Human Health and DiseaseSemantic proximity Read

Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.Semantic proximity Read

Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutationsSemantic proximity Read

Transcriptome analysis of alternative splicing-coupled nonsense-mediated mRNA decay in human cells reveals broad regulatory potentialSemantic proximity Read

mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons.Semantic proximity Read

Function of alternative splicing.Semantic proximity Read

Truncated RNA-binding protein production by DUX4-induced systemic inhibition of nonsense-mediated RNA decaySemantic proximity Read

Regulation of alternative splicing by the core spliceosomal machinery.Semantic proximity Read

Nonsense Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells with SF3B1 and U2AF1 MutationsSemantic proximity Read

Exon junction complex-associated multi-adapter RNPS1 nucleates splicing regulatory complexes to maintain transcriptome surveillanceSemantic proximity Read

Direct and indirect effects of spliceosome disruption compromise gene regulation by Nonsense-Mediated mRNA DecaySemantic proximity Read

An alternative UPF1 isoform drives conditional remodeling of nonsense-mediated mRNA decaySemantic proximity Read