Nanopore sequencing reveals endogenous NMD-targeted isoforms in human cells

Abstract excerpt

<h4>Background</h4> Nonsense-mediated mRNA decay (NMD) is a eukaryotic, translation-dependent degradation pathway that targets mRNAs with premature termination codons and also regulates the expression of some mRNAs that encode full-length proteins. Although many genes express NMD-sensitive transcripts, identifying them based on short-read sequencing data remains a challenge. <h4>Results</h4> To identify and anal...

Topics

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• Cell Transformation, Neoplastic
• Combined Modality Therapy
• Disease Management
• Disease Susceptibility
• Molecular Targeted Therapy
• RNA and protein synthesis mechanisms
• RNA Research and Splicing
• Viral Infections and Immunology Research

Identifiers and source

Literature Corpus work

d3871f0e-88da-5f3f-8f4a-7a1a03aa5760

DOI

10.1101/2021.04.30.442116