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Article

Selection for or against escape from nonsense mediated decay is a novel signature for the detection of cancer genes.

Cancer genetics - 1 Nov 2021

Kumar Runjun D, Burns Briana A, Vandeventer Paul J, Luna Pamela N, Shaw Chad A

Abstract excerpt

Escape from nonsense mediated mRNA decay (NMD-) can produce activated or inactivated gene products, and bias in rates of escape can identify functionally important genes in germline disease. We hypothesized that the same would be true of cancer genes, and tested for NMD- bias within The Cancer Genome Atlas pan-cancer somatic mutation dataset. We identify 29 genes that show significantly elevated or suppressed...

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Identifiers

PMID: 34592632
DOI: 10.1016/j.cancergen.2021.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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