Article

MYCN and helicases DDX17 and DDX5 have opposite effects on the production of readthrough-associated chimeric transcripts

2025-11-13

Abstract excerpt

<title>Abstract</title> <p> DEAD box helicases DDX17 and DDX5 control transcription termination and the associated processing of the 3' end of pre-messenger RNAs. Here we show that the transcriptional readthrough induced by their depletion in neuroblastoma cells results in increased production of chimeric transcripts from tandemly orientated genes, or tracRNAs. Analysis of neuroblastoma tumours in which tracRNAs...

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Literature Corpus work: 7ec6afaf-3af8-5efe-81cd-4a06236e9286
DOI: 10.21203/rs.3.rs-7982361/v1

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