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Article

Nonsense-mediated RNA decay and its bipolar function in cancer.

Molecular cancer - 29 Apr 2021

Nogueira Gonçalo, Fernandes Rafael, García-Moreno Juan F, Romão Luísa

Abstract excerpt

Nonsense-mediated decay (NMD) was first described as a quality-control mechanism that targets and rapidly degrades aberrant mRNAs carrying premature termination codons (PTCs). However, it was found that NMD also degrades a significant number of normal transcripts, thus arising as a mechanism of gene expression regulation. Based on these important functions, NMD regulates several biological processes and is...

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Identifiers

PMID: 33926465
DOI: 10.1186/s12943-021-01364-0
PMCID: PMC8082775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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