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Transcriptome analysis of alternative splicing-coupled nonsense-mediated mRNA decay in human cells reveals broad regulatory potential

2020-07-02

Abstract excerpt

To explore the regulatory potential of nonsense-mediated mRNA decay (NMD) coupled with alternative splicing, we globally surveyed the transcripts targeted by this pathway via RNA-Seq analysis of HeLa cells in which NMD had been inhibited. We identified putative NMD-targeted transcripts as those with a termination codon more than 50 nucleotides upstream of an exon-exon junction (premature termination as defined by...

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Literature Corpus work
3b9a113a-3f40-5b0a-b2cf-ef6be0ff6ff7
DOI
10.1101/2020.07.01.183327
Open publication

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Transcriptome analysis of alternative splicing-coupled nonsense-mediated mRNA decay in human cells reveals broad regulatory potentialDOI 10.1101/2020.07.01.183327
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