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Article

Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis.

Nature communications - 15 Aug 2019

Vedanayagam Jeffrey, Chatila Walid K, Aksoy Bülent Arman, Majumdar Sonali, Skanderup Anders Jacobsen, Demir Emek, Schultz Nikolaus, Sander Chris, Lai Eric C

Abstract excerpt

Somatic mutations in the RNase IIIb domain of DICER1 arise in cancer and disrupt the cleavage of 5' pre-miRNA arms. Here, we characterize an unstudied, recurrent, mutation (S1344L) in the DICER1 RNase IIIa domain in tumors from The Cancer Genome Atlas (TCGA) project and MSK-IMPACT profiling. RNase IIIa/b hotspots are absent from most cancers, but are notably enriched in uterine cancers. Systematic analysis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31417090
DOI: 10.1038/s41467-019-11610-1
PMCID: PMC6695490

Genes

DICER1
IMPACT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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