Structural and functional basis of the non-canonical human Dicer-tRNA complex

Abstract excerpt

Human Dicer (hDicer) is a key enzyme in the RNA interference (RNAi) pathway that generates ~21-22 nt micro-RNA (miRNAs) and small interfering RNAs (siRNAs). We have previously shown that hDicer also generates tRNA-derived small RNAs (tsRNAs), which mediate nuclear gene silencing and regulate hundreds of disease-associated genes. As powerful and evolutionarily conserved cellular regulators, tsRNAs emerged as an imp...

Topics

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• Cryoelectron Microscopy
• DEAD-box RNA Helicases
• MicroRNAs
• Mutation
• Ribonuclease III
• RNA, Double-Stranded
• RNA Precursors
• Substrate Specificity

Identifiers and source

Literature Corpus work

67645ba5-b046-5922-8a1c-22976a972b00

DOI

10.64898/2026.08.12.744379