Article
A slow dynamic RNA switch regulates processing of microRNA-21
2021-12-07
Abstract excerpt
The microRNAs are non-coding RNAs which post-transcriptionally regulate the expression of a majority of eukaryotic genes, and whose dysregulation is a driver of many human diseases. Here we report the discovery of a very slow (0.1 sec) conformational rearrangement at the Dicer cleavage site of pre-miR-21 which regulates the relative concentration of readily processed and inefficiently processed structural states....
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Identifiers and source
- Literature Corpus work
- 2aa99495-2723-5492-8a9d-8e70831bae25
- DOI
- 10.1101/2021.12.07.471640