Article

Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality

2022-01-22

Abstract excerpt

The human brain is a complex, three-dimensional structure. To better recapitulate brain complexity, recent efforts have focused on the development of human specific midbrain organoids. Human iPSC-derived midbrain organoids consist of differentiated and functional neurons, which contain active synapses, as well as astrocytes and oligodendrocytes. However, the absence of microglia, with their ability to remodel neur...

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Identifiers and source

Literature Corpus work: 09bf00e6-281a-56f9-aa1d-058ea622e4b2
DOI: 10.1101/2022.01.21.477192

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