Article

A Human iPSC-derived Organoid System to Model Myelin Destruction and Repair

2024-05-20

Abstract excerpt

We engineered a novel human iPSC-derived organoid system enriched with mature, myelinating oligodendrocytes and functionally reactive microglia. This model enables the study of human CNS remyelination following a demyelinating insult, encapsulating: myelin fragmentation, microglial clearance of myelin debris and oligodendrocyte genesis, differentiation, and axon ensheathment. This system provides a powerful and un...

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Literature Corpus work: 2782384a-4ae9-576f-af5d-eb7ee881a7eb
DOI: 10.1101/2024.05.19.594912

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