Article

Midbrain microglia-integrated organoids as a next-generation tool for chronic morphine withdrawal research: A pilot study

2025-10-31

Abstract excerpt

In the midst of an opioid epidemic, opioid use disorder (OUD) can lead to significant clinical impairment or distress (such as opioid dependence and/or addiction) and overdose deaths. Therefore, it is significant to elucidate the exact molecular mechanisms of OUD and identify more effective therapies. Human induced pluripotent stem cell (hiPSC)-derived organoids are self-organized 3D tissues and mimic in vivo hum...

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Literature Corpus work: 1fdfba7b-fcc2-535f-beeb-0348ba15ea57
DOI: 10.1101/2025.10.30.685622

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