Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in Tauopathy

7 Apr 2020

Abstract excerpt

Neuroinflammatory processes play an integral role in the exacerbation and progression of pathology in tauopathies, a class of neurodegenerative disease characterized by aggregation of hyperphosphorylated tau protein. The RNA binding protein (RBP) T-cell Intracellular Antigen 1 (TIA1) is an important regulator of the innate immune response in the periphery, dampening cytotoxic inflammation and apoptosis during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Immune Response and Inflammation
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32327969
DOI: 10.3389/fnins.2020.00285

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduction of the RNA Binding Protein TIA1 Exacerbates Neuroinflammation in TauopathyPMID 32327969Read ↗

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo.Semantic proximity Read ↗

TIA1 Mediates Divergent Inflammatory Responses to Tauopathy in Microglia and MacrophagesSemantic proximity Read ↗

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and ToxicitySemantic proximity Read ↗

Roles of tau protein in health and diseaseSemantic proximity Read ↗

Tau; One Protein, So Many DiseasesSemantic proximity Read ↗

TIA1-mediated stress granules promote neurodegeneration by sequestering HSP70 mRNA in C9orf72 miceSemantic proximity Read ↗

MAIT cell deficiency exacerbates neuroinflammation in P301S human tau transgenic miceSemantic proximity Read ↗

Neuroimmune proteins can differentiate between tauopathiesSemantic proximity Read ↗

LRP1 Triggers Pro-inflammatory Cell-signaling in Response to Extracellular Tau Independently of the NMDA ReceptorSemantic proximity Read ↗

Tau Oligomers Associate with Inflammation in the Brain and Retina of Tauopathy Mice and in Neurodegenerative Diseases.Semantic proximity Read ↗

Differential interactome mapping of aggregation prone/prion-like proteins under stress: novel links to stress granule biologySemantic proximity Read ↗

CD8+ T-cells infiltrate Alzheimer’s disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.