Article

G3BP1 Maintains Lysosomal Homeostasis to Limit Tau Aggregate Accumulation

2025-08-31

Abstract excerpt

Tau aggregation is a pathological hallmark of a group of neurodegenerative diseases collectively termed tauopathies. While impaired proteostasis is known to drive the accumulation of abnormal proteins, the molecular factors influencing Tau aggregate clearance remain incompletely understood. In this study, we employed a cell-based Tau reporter assay combined with a lentivirus-based pooled CRISPR-Cas9 loss-of-functi...

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Literature Corpus work: 72e317f1-c802-5e1c-adce-f9c08b566e4a
DOI: 10.1101/2025.08.29.672259

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