Article

Beyond A and B Compartments: how major nuclear locales define nuclear genome organization and function

2024-04-23

Abstract excerpt

Models of nuclear genome organization often propose a binary division into active versus inactive compartments yet typically overlook nuclear bodies. Here we integrated analysis of sequencing and image-based data to compare genome organization in four human cell types relative to three different nuclear locales: the nuclear lamina, nuclear speckles, and nucleoli. Whereas gene expression correlates mostly with nucl...

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Literature Corpus work: e23ec6e7-fc49-58a9-a7cb-4e733802410e
DOI: 10.1101/2024.04.23.590809

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