Article

Inflammation-enhanced synapse-specific phagocytosis by adult APP microglia in a microfluidic neuron–microglia co-culture model

2025-08-23

Abstract excerpt

Microglia play a critical role in synapse remodeling and neuroinflammation, both of which are dysregulated in Alzheimer’s disease (AD). However, most in vitro models rely on neonatal or immortalized microglia, limiting their relevance to adult pathophysiological context. Here, we present a compartmentalized microfluidic co-culture platform that enables spatially controlled interactions between primary cortical neu...

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Identifiers and source

Literature Corpus work: 094dd2be-0172-57aa-9103-81a0eb284471
DOI: 10.1101/2025.08.19.671013

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Inflammation-enhanced synapse-specific phagocytosis by adult APP microglia in a microfluidic neuron–microglia co-culture modelDOI 10.1101/2025.08.19.671013Read

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