Back to search

Article

Human iPSC-based coculture model reveals neuroinflammatory crosstalk between microglia and astrocytes

2025-01-03

Abstract excerpt

<h4>Background</h4> Microglia and astrocytes have been implicated as central mediators of neuroinflammatory processes in several neurodegenerative diseases. However, their intricate crosstalk and contributions to pathogenesis remain elusive, highlighting the need for innovative in vitro approaches for investigating glial interactions in neuroinflammation. The aim of this study was to develop advanced human-based...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9400927f-b92a-5b1f-b7b8-e13230161693
DOI
10.1101/2025.01.03.628608
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Human iPSC-based coculture model reveals neuroinflammatory crosstalk between microglia and astrocytesDOI 10.1101/2025.01.03.628608
Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system.Semantic proximity
The tri-culture system reveals an activation cascade from microglia through astrocytes to neurons during neuroinflammationSemantic proximity
An Integrated Neuroimmune Assembloid Model to Advance Neurodegenerative Disease StudiesSemantic proximity
Long-term co-maturation of stem cell-derived microglia and neuronal networks: an optimized platform to assess human microglial contribution to neuronal functionSemantic proximity
Microglia integrated neural spheroids enable neuroinflammatory responses and correct network dysfunction induced by alpha-synuclein mutationSemantic proximity
Defined human tri-lineage brain microtissuesSemantic proximity
Activation of glial cells induces proinflammatory properties in brain capillary endothelial cellsSemantic proximity
Inflammation-enhanced synapse-specific phagocytosis by adult APP microglia in a microfluidic neuron–microglia co-culture modelSemantic proximity
HIV-1 infection promotes neuroinflammation and neuron pathogenesis in novel microglia-containing cerebral organoidsSemantic proximity
Integration of iPSC-derived microglia into human midbrain organoids enhances microglial maturation and inflammatory signalingSemantic proximity
Microfluidics-free single-cell genomics reveals complex central-peripheral immune crosstalk in the mouse brain during peripheral inflammationSemantic proximity
Human iPSC-derived brain pericytes exhibit differences in inflammatory activation compared to primary human brain pericytesSemantic proximity
Select a neighboring publication to make it the new centre.