Article

Microglia-dependent presynaptic disruption in an organotypic hippocampal slice culture model of neuroinflammation

2018-12-20

Abstract excerpt

<h4>Background: </h4> Systemic inflammation, such as occurs during sepsis, bone fracture, infections or post-operative trauma, has been linked to synapse loss and cognitive decline in human patients and animal models. Organotypic hippocampal slice cultures (OHSCs) represent an underused tool in neuroinflammation; retaining much of the neuronal architecture, synaptic connections and diversity of cell types present...

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Literature Corpus work: 1f4f62d1-bd52-5931-ba25-c68f1cb44ce3
DOI: 10.1101/502559

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