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Microglia in Alzheimer’s disease: pathogenesis, mechanisms, and therapeutic potentials

15 Jun 2023

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by protein aggregation in the brain. Recent studies have revealed the critical role of microglia in AD pathogenesis. This review provides a comprehensive summary of the current understanding of microglial involvement in AD, focusing on genetic determinants, phenotypic state, phagocytic capacity, neuroinflammatory response, and impact on...

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PMID: 37396657
DOI: 10.3389/fnagi.2023.1201982

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