Article

The co-chaperone DNAJA2 buffers proteasomal degradation of cytosolic proteins with missense mutations

2024-02-16

Abstract excerpt

Mutations can result in the loss of a protein’s native function due to protein misfolding, which is generally handled by an intricate protein quality control network. To better understand the triaging mechanisms of misfolded cytosolic proteins, we screened a human mutation library to identify a panel of unstable mutations. The degradation of these mutated cytosolic proteins is largely dependent on the ubiquitin pr...

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Literature Corpus work: 68fa8a00-3474-5dcf-83ab-9eec4e10f92e
DOI: 10.1101/2024.02.15.580437

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