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Article

The dTAG system for immediate and target-specific protein degradation.

Nature chemical biology - 1 May 2018

Nabet Behnam, Roberts Justin M, Buckley Dennis L, Paulk Joshiawa, Dastjerdi Shiva, Yang Annan, Leggett Alan L, Erb Michael A, Lawlor Matthew A, Souza Amanda, Scott Thomas G, Vittori Sarah, Perry Jennifer A, Qi Jun, Winter Georg E, Wong Kwok-Kin, Gray Nathanael S, Bradner James E

Abstract excerpt

Dissection of complex biological systems requires target-specific control of the function or abundance of proteins. Genetic perturbations are limited by off-target effects, multicomponent complexity, and irreversibility. Most limiting is the requisite delay between modulation to experimental measurement. To enable the immediate and selective control of single protein abundance, we created a chemical biology...

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Identifiers

PMID: 29581585
DOI: 10.1038/s41589-018-0021-8
PMCID: PMC6295913

Genes

BRD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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