Article

Hijacking Methyl Reader Proteins for Nuclear-Specific Protein Degradation

2022-01-27

Abstract excerpt

Targeted protein degradation (TPD) by PROTACs is a promising strategy to control disease-causing protein levels within the cell. While TPD is emerging as an innovative drug discovery paradigm, there are currently only a limited number of E3 ligase: ligand pairs that are employed to induce protein degradation. Herein, we report a novel approach to induce protein degradation by hijacking a methyl reader: E3 ligase c...

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Literature Corpus work: 72e168fc-acd8-5574-b024-e3d931a36c68
DOI: 10.1101/2022.01.24.477424

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