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Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesis

2026-01-14

Abstract excerpt

<h4>ABSTRACT</h4> Many E3 ubiquitin ligases recognize cognate degron motifs located at protein termini, but the paucity of bona fide substrates of N-degron and C-degron pathways hampers our understanding of their physiological significance. Here, by devising an expression screening approach to assess the effect of C-terminal “capping” on the stability of thousands of human proteins, we systematically identify a...

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Literature Corpus work
ce4980c3-d65c-58fb-b656-be674c64d70f
DOI
10.64898/2026.01.14.698769
Open publication

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Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesisDOI 10.64898/2026.01.14.698769
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