Article

Dual Bmp-negative feedback loops modulate both AER and ZPA function to buffer and constrain postaxial digit number

2025-07-22

Abstract excerpt

<h4>ABSTRACT</h4> Several lines of evidence indicate that posterior (postaxial) digit number in tetrapod vertebrates is constrained to the pentadactyl state by interactions between the 2 major signaling centers that organize digit pattern and growth, the Shh-expressing ZPA and the Fgf-expressing AER ectoderm. Negative short-range effects of Shh on the immediately overlying AER limit its posterior extent and funct...

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Literature Corpus work: 08cbecb5-a8eb-5e10-86ff-c7830d06002e
DOI: 10.1101/2025.07.17.665402

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