Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds.

Nature - 7 Oct 1999

Zúñiga A, Haramis A P, McMahon A P, Zeller R

Abstract excerpt

Outgrowth and patterning of the vertebrate limb are controlled by reciprocal interactions between the posterior mesenchyme (polarizing region) and a specialized ectodermal structure, the apical ectodermal ridge (AER). Sonic hedgehog (SHH) signalling by the polarizing region modulates fibroblast growth factor (FGF)4 signalling by the posterior AER, which in turn maintains the polarizing region (SHH/FGF4 feedback...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Culture Techniques
Share to Ectoderm
Share to Feedback

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fetal Proteins

Share to Fibroblast Growth Factors

Share to Formins

Share to Limb Buds

Share to Xenopus Proteins

Source

Identifiers

PMID: 10524628
DOI: 10.1038/44157

Genes

SHH
FGF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds.PMID 10524628Read ↗

Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning.Semantic proximity Read ↗

Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.Semantic proximity Read ↗

Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth.Semantic proximity Read ↗

Some distal limb structures develop in mice lacking Sonic hedgehog signaling.Semantic proximity Read ↗

Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signalling.Semantic proximity Read ↗

The limb deformity mutation disrupts the SHH/FGF-4 feedback loop and regulation of 5' HoxD genes during limb pattern formation.Semantic proximity Read ↗

Anteroposterior patterning in the limb and digit specification: contribution of mouse genetics.Semantic proximity Read ↗

Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb.Semantic proximity Read ↗

Phylogenetic conservation of a limb-specific, cis-acting regulator of Sonic hedgehog ( Shh).Semantic proximity Read ↗

FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds.Semantic proximity Read ↗

Dual Bmp-negative feedback loops modulate both AER and ZPA function to buffer and constrain postaxial digit numberSemantic proximity Read ↗

Dynamics of BMP signaling in limb bud mesenchyme and polydactyly.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.