Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds.

doi:10.1038/44157

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Article

Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds.

Nature - 7 Oct 1999

Zúñiga A, Haramis A P, McMahon A P, Zeller R

Abstract excerpt

Outgrowth and patterning of the vertebrate limb are controlled by reciprocal interactions between the posterior mesenchyme (polarizing region) and a specialized ectodermal structure, the apical ectodermal ridge (AER). Sonic hedgehog (SHH) signalling by the polarizing region modulates fibroblast growth factor (FGF)4 signalling by the posterior AER, which in turn maintains the polarizing region (SHH/FGF4 feedback...

Topics

Animals
Bone Morphogenetic Proteins
Carrier Proteins
Cell Line
Chickens
Culture Techniques
Cytokines
Ectoderm
Feedback
Fetal Proteins
Fibroblast Growth Factor 4
Fibroblast Growth Factors
Formins
Hedgehog Proteins
Humans

Source

Open in PubMed

Identifiers

PMID: 10524628
DOI: 10.1038/44157

Genes

SHH
FGF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intercellular Signaling Peptides and Proteins

Limb Buds

Mice