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Article

Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud.

Developmental cell - 1 Apr 2008

Zhu Jianjian, Nakamura Eiichiro, Nguyen Minh-Thanh, Bao Xiaozhong, Akiyama Haruhiko, Mackem Susan

Abstract excerpt

Sonic hedgehog (Shh), which regulates proliferation in many contexts, functions as a limb morphogen to specify a distinct pattern of digits. How Shh's effects on cell number relate to its role in specifying digit identity is unclear. Deleting the mouse Shh gene at different times using a conditional Cre line, we find that Shh functions to control limb development in two phases: a very transient, early patterning...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18410737
DOI: 10.1016/j.devcel.2008.01.008
PMCID: PMC8284562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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