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Article

FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds.

Developmental cell - 1 Apr 2009

Zhang Zhen, Verheyden Jamie M, Hassell John A, Sun Xin

Abstract excerpt

Anterior-posterior (A-P) patterning of the vertebrate limb is controlled by sonic hedgehog (SHH) signaling, and the precise restriction of Shh expression to the posterior limb bud is essential for its polarizing effect. Fibroblast growth factor (FGF) signaling, a key control of proximal-distal (P-D) limb outgrowth, is known to promote Shh expression in the posterior limb bud. Here, we show that conditional...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 19386269
DOI: 10.1016/j.devcel.2009.02.008
PMCID: PMC3541528

Genes

ETV4
ETV5
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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