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Article

An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth.

Nature - 31 Jul 2008

Verheyden Jamie M, Sun Xin

Abstract excerpt

During organ formation and regeneration a proper balance between promoting and restricting growth is critical to achieve stereotypical size. Limb bud outgrowth is driven by signals in a positive feedback loop involving fibroblast growth factor (Fgf) genes, sonic hedgehog (Shh) and Gremlin1 (Grem1). Precise termination of these signals is essential to restrict limb bud size. The current model predicts a sequence...

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Identifiers

PMID: 18594511
DOI: 10.1038/nature07085
PMCID: PMC2840222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth.PMID 18594511Read ↗

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